Table 58.3. Antineoplastic Drug Typical Dosages, Routes, and Precautions
Name Concentrati Standard Dosage Usual Route Comments
on of
Administration
Asparaginase 2,000 400 units/kg, SQ May cause
ElsparR units/ml not to exceed hypersensitivity,
MSD 10,000 units coagulation
deficit, or
biochemical
hepatotoxicity
Bleomycin 3 units/ml 10 units/m2 SQ Caution if renal or
Sulfate pulmonary disease
BlenoxaneR
Mead-Johnson
Carboplatin 10 mg/ml 300 mg/m2 IV Caution if renal
ParaplatinR disease
Bristol May cause bone
marrow toxicity
Carmustine 3.3 mg/ml 50 mg/m2 IV Delayed
BiCNUR myelosuppression
Bristol Biochemical
hepatoxicity
Cisplatin 1 mg/ml 60 mg/m2 IV Caution in cats
PlatinolR Dose related
Bristol nephrotoxicity
Maintain high urine
flow
Cyclophospham tablets 50 mg/m2 PO x 4 PO Sterile hemorrhagic
ide inj 20 days/week IV cystitis
CytoxanR mg/ml 250 mg/m2 IV q1w Bone marrow
Mead-Johnson suppression
Cytarabine 20 mg/ml 100 mg/m2 q3w IV Bone marrow
CytosarR 50 mg/ml SQ suppression
Upjohn Avoid rapid IV
injection
Dacarbazine 10 mg/ml 1,000 mg/m2 q3w IV Bone marrow
DTICR 200 mg/m2 5 days suppression
Miles q3w Nausea and vomiting
Avoid extravascular
injection
Dactinomycin 0.45 mg/ml 0.6 mg/m2 IV Avoid extravascular
CosmegenR injection
MSD Bone marrow
suppression
Doxorubicin 2 mg/ml 30 mg/m2 (dogs) IV Avoid extravascular
HCL 20 mg/m2 (cats) injection
Leukopenia,
AdriamycinR Cumulative
Adria Labs myocardial toxicity
Fluorouracil 50 mg/ml 200 mg/m2 IV Extreme caution in
5FUR cats
Burroughs- Bone marrow
Wellcome suppression
GI toxicity
Vinblastine 1 mg/ml 2 mg/m2 IV Avoid extravascular
VelbanR injection
Lilly Leukopenia
Vincristine 1 mg/ml 0.5 mg/m2 IV Avoid extravascular
sulfate injection
OncovinR Neurotoxicity
Lilly Constipation
Modified and extended from Bonney and Knapp 1994