PharMingen

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Anti-Human OX40 mAb, clone ACT35

DESCRIPTION

Reacts with a 35 kD polypeptide chain expressed on mitogen stimulated lymphocytes. OX40 is a member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. Analysis of the nucleoside sequence of the human cDNA revealed strong homology with rat OX40 cDNA. OX40 may play a role in T-cell activation as well as regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells. This antibody is suitable for staining formalin-fixed, paraffin embedded tissue sections with citrate pretreatment.(1-3)

USAGE

This reagent is effective for immunofluorescence staining of human tissue for flow cytometric analysis and fluorescence microscopy, as well as for for staining formalin-fixed, paraffin embedded tissue sections with citrate pretreatment. Since applications vary, each investigator should titrate the reagent to obtain optimal results.

For Research Use Only. Not For Diagnostic or Therapeutic Use.

REFERENCES
1. Knapp, W. , B. Dorken, E. P. Rieber, et al. , eds . 1989. Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York.
2. Schlossman, S., L. Boumsell, W. Gilks, et al. , eds . 1995 Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press, New York.
3. Latza, U., H. Durkop, S. Schnittger, et al . 1994. The human OX40 homolog: DNA structure, expression and chromosomal assignment of the ACT35 antigen. Eur. J. Immunol. 24: 677.

Cat. No. Description Clone Isotype Size
34461A Purified anti-human OX40 ACT35 Mouse IgG1 0.1mg

Available soon: FITC and PE formats

PharMingen also supplies the following antibodies specific for Activation/Proliferation-Associated Markers:
CD25 CD71
CD26 CD97
CD30 CD122
CD38 PCNA
CD69 Ki-67
CDw70 BrdU

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu