Anti-human IL-8 RA (CXCR1), clone 5A12 and Anti-human IL-8 RB (CXCR2), clone 6C6

DESCRIPTION

Anti-human IL-8 RA (CXCR1), clone 5A12: Reacts with Interleukin-8 receptor A (IL-8RA), a G-protein-linked seven transmembrane domain protein, expressed on monocytes and granulocytes. It is also expressed on a subset of T cells. Both IL-8RA and IL-8RB are high affinity receptors for IL-8. IL-8 is an inflammatory cytokine which induces chemotaxis of neutrophils, basophils and T lymphocytes.(1-4)

Anti-human IL-8 RB (CXCR2), clone 6C6: Reacts with interleukin-8 receptor B (IL-8R B), a heptaspan transmembrane protein, expressed on monocytes and granulocytes. It is also expressed on a subset of T cells. IL-8 is an inflammatory cytokine which induces chemotaxis of neutrophils, basophils and T lymphocytes.(1,2)

USAGE

These reagents are effective for indirect immunofluorescence staining of human cells for flow cytometric analysis and fluorescence microscopy. Since applications vary, each investigator should titrate the reagents to obtain optimal results.

For Research Use Only. Not For Diagnostic or Therapeutic Use.

REFERENCES
1. Qin, S., G. LaRosa, J.J. Campbell, et al. 1996. Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T cells: correlation with transendothelial chemotactic potential. Eur. J. Immunol. 26: 640.
2. Barclay, N.A., M.L. Birkeland, M.H. Brown, et al. 1993. The Leucocyte Antigen Facts Book. Academic Press. p. 340
3. Callard, R., and A. Gearing. 1994. The Cytokine Factsbook. Academic Press. p. 75.
4. Baggiolini, M., P. Loetscher and B. Moser. 1995. Int. J. Immunopharmac. 17:103.

Cat. No. Description Isotype Isotype Size
35781D Purified anti-human IL-8 RA (CXCR1) 5A12 Mouse IgG2b 0.5mg
35740D Purified anti-human IL-8 RB (CXCR2), NA/LE* 6C6 Mouse IgG1, lambda 0.5mg
35741D Purified anti-human IL-8 RB (CXCR2) 6C6 Mouse IgG1, lambda 0.5mg
35745B PE labelled anti-human IL-8 RB (CXCR2) 6C6 Mouse IgG1, lambda 0.2mg

* NA/LE = No Azide/Low Endotoxin for functional studies

PharMingen supplies a complete line of reagents for cytokine and chemokine analysis, including:

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