DESCRIPTION
Reacts with a 35 kD polypeptide chain expressed on mitogen stimulated lymphocytes. OX40 is a member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. Analysis of the nucleoside sequence of the human cDNA revealed strong homology with rat OX40 cDNA. OX40 may play a role in T-cell activation as well as regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells. This antibody is suitable for staining formalin-fixed, paraffin embedded tissue sections with citrate pretreatment.(1-3)
USAGE
This reagent is effective for immunofluorescence staining of human tissue for flow cytometric analysis and fluorescence microscopy, as well as for for staining formalin-fixed, paraffin embedded tissue sections with citrate pretreatment. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
REFERENCES
1. Knapp, W. , B. Dorken, E. P. Rieber, et al., eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York.
2. Schlossman, S., L. Boumsell, W. Gilks, et al., eds. 1995 Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press, New York.
3. Latza, U., H. Durkop, S. Schnittger, et al. 1994. The human OX40 homolog: DNA structure, expression and chromosomal assignment of the ACT35 antigen. Eur. J. Immunol. 24: 677.
| Cat. No. | Description | Clone | Isotype | Size |
| 34461A | Purified anti-human OX40 | ACT35 | Mouse IgG1 | 0.1mg |
PharMingen also supplies the following antibodies specific for Activation/Proliferation-Associated Markers:
CD25
CD71
CD26
CD97
CD30
CD122
CD38
PCNA
CD69
Ki-67
CDw70
BrdU
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