Human Recombinant SDF-1alpha

SDF-1alpha (stromal derived factor) is a member of the CXC group of chemokines and was originally characterized as a pre-B cell stimulatory factor (PBSF) derived from bone marrow stromal cells.

SDF-1a was recently identified as the ligand for fusin (CXCR4).(1,2) SDF-1alpha is chemotactic for lymphocytes and monocytes and has been shown to block infection of T cells by HIV-1.(1)

Cat. No. Description Size
23081T Recombinant Human SDF-1alpha 10ug
23081N Recombinant Human SDF-1alpha 50ug

For Research Use Only. Not For Diagnostic or Therapeutic Use.

REFERENCES

  1. C.C. Bleul, et al., Nature 382, 829-833 (1996).
  2. E. Oberlin, et al., Nature 382, 829-833 (1996).
  3. C.C Bleul, R. C. Fuhlbrigge, J. M. Casasnovas, A. Aiuti, T. A.Springer, J. Exp. med. 184, 1101-1109 (1996).

PharMingen also offers the following Reagents for Chemokine Research

Chemotaxis of human T cells in response to SDF-1alpha. T cells were prepared from human peripheral blood. Chemotaxis in response to human synthetic SDF-1alpha was determined using a multiwell chemotaxis chamber and a 5uM polycarbonate filter, coated on the lower side with mouse type IV collagen. 8 high power (400x) fields were counted for each concentration of SDF-1alpha used.

 

 

 

 

 

 

 

 

 

 

 

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