Detecting auto / allo antibodies

R Barclay (Robin_Barclay@compuserve.com)
Wed, 5 Nov 1997 19:50:29 -0500

Would anyone care to recommend fluorochrome-labelled anti-human Ig
antibodies for detecting cell/platelet bound antibodies, and (preferably)=

distinguishing specific from non-specific binding. I have started to
tinker with some anti-IgG-Fc (Fab) - but am experiencing horrific
backgrounds at first attempts - so any tips/tricks on blocking, pre- or
post -stain fix, whether whole blood techniques are common, and if so -
when to lyse. What are people using in detection of leucocyte or platele=
t
antibodies, flow crossmatches, etc?
Robin Barclay
Blood Transfusion Service
Edinburgh